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PDE5 is an enzyme establish chiefly in the suave muscular tissue of
the principal cavernosum that selectively cleaves and degrades cGMP to 5′-GMP.
PDE5 inhibitors are like in anatomical structure to cGMP; they competitively
tie up to PDE5 and conquer cGMP hydrolysis, frankincense enhancing the effects of NO.
This increase in cGMP in the smooth out muscle
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